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IMPURITIES
 
STANDARDS OF RELATED SUBSTANCE/METABOLITE
 
Sr. No. Name CAS No. BP
Code		 USP
Code		 EP
Code
ALLOPURINOL*
1 5-Amino-1H-pyrazole-4-carboxamide 5334-31-6 - A A
2 5-(formylamino)-1H-pyrazole-4-carboxamide 22407-20-1 - B B
3 Ethyl-5-amino-1H-pyrazole-4-carboxylate 6994-25-8 - D D
4 Ethyl-5-(formylamino)-1H-pyrazole-4-carboxylate 31055-19-3 - E E
5 Ethyl-(E/Z)-3-(2-carbethoxy-2-cyanoethenyl)-amino-1H-pyrazole-4-carboxylate 321571-07-7 - F -
AMODIAQUINE HYDROCHLORIDE*
6 7-chloro-4-(4-hydroxy phenyl amino)-Quinoline - - - -
7 N-{3-[(diethylamino)methyl]-4-hydroxyphenyl}-acetamide - - - -
8 N-(4-hydroxyphenyl)-acetamide [Paracetamol] 8055-08-1 - - -
9 4,7-Dichloroquinoline 86-98-6 - - -
ARETEMETHER*/ARTESUNATE*/ DIHYDROARTEMISININ*
10 Artemisinin 63968-64-9 - - -
11 Dihydroartemisinin 81496-81-3 - - -
12 α - Artemether 71939-51-0 - - -
BISOPROLOL FUMARATE*
13 (RS)-1-(4-Hydroxymethylphenoxy)-3-isopropylaminopropan-2-ol 62572-93-4 - - A
14 (RS)-1-Isopropylamino-3-[4-(2-propoxyethoxymethyl)phenoxy] propan-2-ol - - - B
CLOPIDOGREL BISULPHATE*
15 (+) –(S)- a-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine -5(4H)-acetic acid  hydrochloride 144750-42-5 - A -
16 Methyl (+) a-(2-Chlorophenyl)-4,5-dihydrothieno[2,3-c]pyridine -6(7H)-acetate. hydrochloride 144750-52-7 - B -
17 Methyl (-) –(R)-a-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine -5(4H)-acetate. Hydrogen sulfate 120202-71-3 - C -
4,7-DICHLOROQUINOLINE
18 4,5-Dichloroquinoline 21617-18-5 - - -
FUROSEMIDE*
19 2,4 dichloro-5-Sulphamoyl benzoic acid [Lasamide] 2736-23-4 - - B
20 2-amino-4-chloro-5-Sulphamoyl benzoic acid 3086-91-7 - - C
21 2,4-dichlorobenzoic acid 50-84-0 - - E
21 4-chloro-5-sulfamoylanthranilic acid 3086-91-7 - B -
HYDROXYCHLOROQUINE SULPHATE*
23 4,7-Dichloroquinoline 86-98-6 - - -
LUMEFANTRINE*
24 2,7-dichloro-4-fluorenyl ketone 7012-16-0 - - -
25 2-chloro-1-(2,7-dichloro-9H-fluoren-4-yl)-ethanone - - - -
26 2-dibutylamino-1-(2,7-dichloro-9H-fluoren-4-yl)-ethanol 69759-61-1 - - -
27 4-Chloro benzaldehyde 104-88-1 - - -
NIMESULIDE*
28 N-(2,4-Dinitro-6-phenoxyphenyl)-methanesulphonamide - A - A
29 N-(2-phenoxyphenyl)-methanesulphonamide 51765- 51-6 B - B
30 2-phenoxyaniline 2688-84-8 C - C
31 4-nitro-2-phenoxyphenol 70995-08-3 D - D
32 N,N’-(bis methylsulfonyl)-2-phenoxy aniline - E - E
33 N,N’-(bis methylsulfonyl)-2-phenoxy-4-nitro aniline 51765-72-1 F - F
PIPERAQUINE PHOSPHATE*
34 4,7-Dichloroquinoline 86-98-6 - - -
35 7-chloro-4-piperazinyl quinoline 837-52-5 - - -
36 1,4-bis-(4,7-dichloroquinoline)piperazine - - - -
TENEFOVIR DISOPROXIL FUMARATE*
37 [Tenofovir]
(R)-[1-(6-Amino-9H-purin-9-yl) propan-2-yloxy] methylphosphonic acid 		147127-20-6 - - -
38 [Tenofovir isoproxil monoester]
({[(R) -1-(6-Amino-9H-purin-9-yl) propan-2-yloxy] methyl} (hydroxy) phosphoryloxy) methyl isopropyl carbonate 		211364-69-1 - - -
39 [Tenofovir isopropyl isoproxil]
O-(Isopropoxycarbonyloxymethyl)-O-isopropyl-{(R)-[1-(6-amino-9H-purin-9-yl) propan-2-yloxy]}methylphosphonate 		1246812-40-7 - - -
40 [Tenofovir disoproxil ethyl ester]
O-(Ethoxycarbonyloxymethyl)-O-(isopropoxycarbonyloxymethyl)-{(R)-[1-(6-amino-9H-purin-9-yl) propan-2-yloxy]}methylphosphonate		 - - - -
41 [Tenofovir disoproxil carbamate]
O, O-Bis (isopropoxycarbonyloxymethyl){(R)-1-[(6-isopropoxycarbonyl amino)-9H-purin-9yl] propan-2-yloxy]}methylphosphonate		 1244022-54-5 - - -
42 [Tenofovir Disoproxil Related compound-B]
((E)-9-(Prop-1-enyl)-9H-purin-6-amine)		 4121-40-8      
43 [Adenine]
9H-purin-6-amine		 73-24-5 - - -
* Standard of API is also available
 


 
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